Ealing Council has granted consent to plans for 9-42 The Broadway by Londonnewcastle working with Benson Elliot.
The plans will produce 188 homes (of which 51 will be affordable), 20 new retail units and a 5,000 square feet music venue.
The plans were approved despite objections from Historic England, the Victorian Society, Ealing Civic Society, and a number of residents groups.
Plans were amended recently to allow the preservation of a number of victorian buildings and frontages, but around 11 will be demolished to make way for the development.
Work is expected to start in early 2017 and complete in 2019.